Effects of acute and chronic nitric oxide inhibition in an experimental model of chronic pulmonary allergic inflammation in guinea pigs.

@article{Prado2005EffectsOA,
  title={Effects of acute and chronic nitric oxide inhibition in an experimental model of chronic pulmonary allergic inflammation in guinea pigs.},
  author={Carla M Prado and Edna Aparecida Leick-Maldonado and David Itiro Kasahara and Vera L{\'u}cia Capelozzi and Milton A Martins and Iolanda de F{\'a}tima Lopes Calvo Tib{\'e}rio},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2005},
  volume={289 4},
  pages={L677-83}
}
Endogenously produced nitric oxide is a recognized regulator of physiological lung events, such as a neurotransmitter and a proinflammatory mediator. We tested the differences between chronic and acute nitric oxide inhibition by N(omega)-nitro-L-arginine methyl ester (L-NAME) treatment in lung mechanics, inflammation, and airway remodeling in an experimental asthma model in guinea pigs. Both acute and chronic L-NAME treatment reduced exhaled nitric oxide in sensitized animals (P < 0.001… CONTINUE READING