Effects of acute and chronic amphetamine treatment on Purkinje neuron discharge in rat cerebellum.

@article{Freedman1980EffectsOA,
  title={Effects of acute and chronic amphetamine treatment on Purkinje neuron discharge in rat cerebellum.},
  author={Robert Freedman and Jwaharlal Marwaha},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1980},
  volume={212 3},
  pages={390-6}
}
The spontaneous discharge of the cerebellar Purkinje neuron in urethane-anesthetized rats is used as an indicator of central noradrenergic activity during the acute and chronic administration of d-amphetamine. Acute parenteral administration of amphetamine causes a dose-dependent slowing of the discharge. Since this effect is not seen in animals in which the catecholaminergic innervation has been selectively removed by previous treatment with 6-hydroxydopamine, it is hypothesized that the… CONTINUE READING