Effects of acute and chronic administration of MK-801 on c-Fos protein expression in mice brain regions implicated in schizophrenia with or without clozapine.

@article{Zuo2009EffectsOA,
  title={Effects of acute and chronic administration of MK-801 on c-Fos protein expression in mice brain regions implicated in schizophrenia with or without clozapine.},
  author={Dai-ying Zuo and Yue Cao and Lan Zhang and Hai-feng Wang and Yingliang Wu},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2009},
  volume={33 2},
  pages={290-5}
}
This study investigated the effects of acute and chronic administration of the non-competitive NMDA receptor antagonists MK-801 on c-Fos protein expression in different brain regions of mice with or without clozapine. MK-801 (0.6 mg/kg) acute administration produced a significant increase in the expression of c-Fos protein in the layers III-IV of posterior cingulate and retrosplenial (PC/RS) cortex, which was consistent with the previous reports. Moreover, we presented a new finding that MK-801… CONTINUE READING
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