Corpus ID: 25009514

Effects of acute and chronic administration of idazoxan on blood pressure and plasma catecholamine concentrations of rats.

@article{Harland1988EffectsOA,
  title={Effects of acute and chronic administration of idazoxan on blood pressure and plasma catecholamine concentrations of rats.},
  author={D. Harland and M. Brown},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={245 1},
  pages={
          265-73
        }
}
  • D. Harland, M. Brown
  • Published 1988
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • To test the hypothesis that alpha-2 adrenoceptor antagonists can modulate sympathetic nerve release of norepinephrine in vivo through blockade of peripheral prejunctional alpha-2 adrenoceptors, acute and chronic effects of the alpha-2 adrenoceptor antagonist idazoxan on mean arterial pressure (MAP), heart rate and plasma catecholamine concentrations have been investigated in conscious and anesthetized rats. In normotensive rats, a single i.v. dose of idazoxan (300 micrograms kg-1) caused an… CONTINUE READING
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