Effects of acute and chronic administration of cannabis sativa and (−)Δ9-trans-tetrahydrocannabinol on the behavior of rats in an open-field arena

@article{Masur1971EffectsOA,
  title={Effects of acute and chronic administration of cannabis sativa and (−)Δ9-trans-tetrahydrocannabinol on the behavior of rats in an open-field arena},
  author={Jandira Masur and Regina M. W. M{\"a}rtz and Elisaldo Luiz de Ara{\'u}jo Carlini},
  journal={Psychopharmacologia},
  year={1971},
  volume={19},
  pages={388-397}
}
The effects of acute and chronic administration of Δ 9-THC, cannabis extract and control solution on the behavior of rats repeatedly exposed to an open-field arena have been studied. After the first dose both Δ 9-THC and cannabis extract significantly decreased defecation, grooming and rearing; ambulation was not affected. After 20 injections of both marihuana compounds the rats showed values for defecation, grooming and rearing near to those obtained during the predrug phase; control rats… CONTINUE READING
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