Effects of active substances fromStaphylococcus aureus (protein a and peptidoglycan) on neurotransmitter-induced contractions of smooth muscles

Abstract

Modulatory effects of protein A (PA) and peptidoglycan (PG) fromStaphylococcus aureus on the smooth muscle contractions elicited by neurotransmitters were studied. PA and PG were found to suppress the myometrium smooth muscle contractions elicited by acetylcholine applications. The effects of the substances on the contractions were due to non-competitive inhibition through an enhancement of the potassium-dependent conductance of the smooth muscle cell membrane. PA and PG did not affect the myometrium contractions elicited by oxytocin, or the contractions of the coronary arteries elicited by acetylcholine or noradrenaline.

DOI: 10.1007/BF02252559

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Cite this paper

@article{Filippov2005EffectsOA, title={Effects of active substances fromStaphylococcus aureus (protein a and peptidoglycan) on neurotransmitter-induced contractions of smooth muscles}, author={Igor Filippov and Michael F. Shuba and T. L. Davydovskaya and L. S. Kholodnaya and V. K. Pozur and Taras A Lyubchenko}, journal={Neurophysiology}, year={2005}, volume={28}, pages={22-26} }