Effects of active MEK1 expression in vivo.

  title={Effects of active MEK1 expression in vivo.},
  author={Florence A. Scholl and Phillip A. Dumesic and Paul A. Khavari},
  journal={Cancer letters},
  volume={230 1},
Cell transformation is often a result of constitutive activation of genes in signaling pathways that regulate cell proliferation and differentiation. Indeed, the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway is constitutively activated in a large number of cancers. The extent to which a single-gene mutation can alter cell fate, however, remains questionable. In vitro studies have addressed this issue, but organs are comprised of multiple cell types, and in vitro… CONTINUE READING