Effects of activation of endocannabinoid system on myocardial metabolism.

  title={Effects of activation of endocannabinoid system on myocardial metabolism.},
  author={Agnieszka Polak and Ewa Harasim and Adrian Chabowski},
  journal={Postepy higieny i medycyny doswiadczalnej},
  volume={70 0},
Endocannabinoids exert their effect on the regulation of energy homeostasis via activation of specific receptors. They control food intake, secretion of insulin, lipids and glucose metabolism, lipid storage. Long chain fatty acids are the main myocardial energy substrate. However, the heart exerts enormous metabolic flexibility emphasized by its ability to utilzation not only fatty acids, but also glucose, lactate and ketone bodies. Endocannabinoids can directly act on the cardiomyocytes… 
Altered cannabinoid receptor expression in pancreatic islets in experimental model of uremia.
The obtained results indicate the involvement of cannabinoid receptors in the pathomechanism of carbohydrate metabolism disorders, associated with abnormal secretion of hormones by the α and β cells in uremia.
Effects of hypertension and FAAH inhibitor treatment of rats with primary and secondary hypertension considering the physicochemical properties of erythrocytes
Considering the changes in physicochemical parameters of erythrocyte membranes, URB597 can be considered a potential protective factor for ery Throthrocytes in situations of metabolic changes associated with oxidative stress.
How Hypertension Affects Heart Metabolism
It was found that hypertension induces a shift in substrate preference toward increased glucose utilization in cardiac muscle, prior to structural changes development, which may affect energy generation status in the heart.


The role of the endocannabinoid system in lipogenesis and fatty acid metabolism.
  • R. Vettor, C. Pagano
  • Biology
    Best practice & research. Clinical endocrinology & metabolism
  • 2009
Endocannabinoids and the Heart
  • C. Hiley
  • Biology, Chemistry
    Journal of cardiovascular pharmacology
  • 2009
There is potential for therapeutic targeting of endocannabinoids and their receptors, but their apparent involvement in both protective and deleterious actions on the heart means that careful risk assessment is needed before any treatment can be introduced.
The CB1 Endocannabinoid System Modulates Adipocyte Insulin Sensitivity
It is found that insulin‐stimulated phosphorylation of the protein kinase Akt was increased by 2‐AG, attenuated by SR141716, and unaffected in the absence of insulin or by addition of high‐dose insulin, consistent with a model in which the endocannabinoid system sets the sensitivity of the insulin response in adipocytes rather than directly regulating the redistribution of GLUT4 or Akt phosphorylated.
The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity
It is tempting to hypothesize that physical activity would represent a complementary alternative approach for the clinical management of endocannabinoid system deregulation in obesity, without the side effects occurring with CB1 receptor antagonists.
The endocannabinoid system in obesity and type 2 diabetes.
Following unbalanced energy intake, the EC system becomes dysregulated, and in most cases overactive, in several organs participating in energy homeostasis, particularly, in intra-abdominal adipose tissue, which might contribute to excessive visceral fat accumulation and reduced adiponectin release from this tissue.
Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury.
Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis
Central EC tone plays an important role in regulating hepatic and adipose tissue insulin action and results indicate that peripherally restricted CB1 antagonists are also likely to be less effective than brain-permeableCB1 antagonists in ameliorating insulin resistance.
The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans
Novel evidence is provided that FAAH activity in subcutaneous mature adipocytes increases with BMI, whereas MGL activity does not, which supports the hypothesis that some components of the ECS are upregulated with increasing adiposity in humans, and that AEA and 2-AG may be regulated differently.
Endocannabinoids: Some Like it Fat (and Sweet Too)
The emerging role of the endocannabinoid system in energy balance at both central and peripheral levels will be discussed in this review.