Effects of activated macrophages on tumor target cells in discrete phases of the cell cycle.

@article{Krahenbuhl1980EffectsOA,
  title={Effects of activated macrophages on tumor target cells in discrete phases of the cell cycle.},
  author={James L. Krahenbuhl},
  journal={Cancer research},
  year={1980},
  volume={40 12},
  pages={4622-7}
}
Studies were performed in vitro to examine the cytostatic properties of activated macrophages on tumor cells in various phases of the cell cycle. EMT-6 target cells were synchronized in the M phase by mitotic selection techniquese and placed in culture. As the population of target cells proceeded to various discrete phases of the cell cycle in a high degree of synchrony, these cells were challenged with normal macrophages or activated macrophages from Corynebacterium parvum-treated mice, and… CONTINUE READING

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