Effects of actin-myosin kinetics on the calcium sensitivity of regulated thin filaments.

Abstract

Activation of thin filaments in striated muscle occurs when tropomyosin exposes myosin binding sites on actin either through calcium-troponin (Ca-Tn) binding or by actin-myosin (A-M) strong binding. However, the extent to which these binding events contributes to thin filament activation remains unclear. Here we propose a simple analytical model in which… (More)
DOI: 10.1074/jbc.M110.142232

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