Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats.

@article{Camacho2012EffectsOA,
  title={Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats.},
  author={Lu{\'i}sa Camacho and John R. Latendresse and Levan Muskhelishvili and Robert Patton and John F. Bowyer and Monzy Thomas and Daniel R. Doerge},
  journal={Toxicology letters},
  year={2012},
  volume={211 2},
  pages={135-43}
}
Acrylamide (AA) is a reactive monomer used in many technological applications, but it is the incidental formation during cooking of common starchy foods that leads to pervasive human exposure, typically in the range of 1 μg/kg body weight (bw)/day (d). AA is carcinogenic in multiple organs from both sexes of several rodent models and a consistent body of evidence points to a genotoxic mechanism based on metabolism to a DNA-reactive epoxide, glycidamide (GA). In F344 rats, tumorigenesis occurs… CONTINUE READING
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