Effects of acivicin and dipyridamole on hepatoma 3924A cells.

  title={Effects of acivicin and dipyridamole on hepatoma 3924A cells.},
  author={Yong-su Zhen and May S. Lui and George Weber},
  journal={Cancer research},
  volume={43 4},
Dipyridamole inhibited the incorporation of cytidine, thymidine, uridine, and guanosine in rat hepatoma 3924A cells with 50% inhibitory concentrations of 0.2 to 0.5 microM. For deoxycytidine, the 50% inhibitory concentration was about 100 times higher (23.8 microM). Addition of a combination of cytidine, deoxycytidine, and guanosine, at an optimal concentration of 80 microM each, protected the hepatoma cells from the growth-inhibitory action of the antiglutamine drug, acivicin. The protection… CONTINUE READING