Effects of acidic and basic fibroblast growth factors on osteoblastic cells.

@article{Rodan1989EffectsOA,
  title={Effects of acidic and basic fibroblast growth factors on osteoblastic cells.},
  author={Sevgi B. Rodan and G. Wesolowski and Kenneth A. Thomas and Kwon-Ha Yoon and Gideon A. Rodan},
  journal={Connective tissue research},
  year={1989},
  volume={20 1-4},
  pages={283-8}
}
Acidic (a) and basic (b) fibroblast growth factors (FGFs) are two related mitogenic and angiogenic factors. They are multifunctional in that they can affect proliferation and induce or delay differentiation. Both aFGF and bFGF were shown to stimulate proliferation of calvaria cells in situ as well as osteoblast-enriched calvaria-derived cells. bFGF was also found to suppress the expression of alkaline phosphatase, parathyroid hormone stimulatable adenylate cyclase, osteocalcin, and type I… CONTINUE READING

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