Effects of acetylcholine on an animal mode of inflammation.

  title={Effects of acetylcholine on an animal mode of inflammation.},
  author={A. S. Silva-Herdade and Carlota Saldanha},
  journal={Clinical hemorheology and microcirculation},
  volume={53 1-2},
Acetylcholinesterase (AChE) is found both on the membranes of neuronal and non-neuronal cells. In this study we performed intravenous administrations of velnacrine (VLN) and acetylcholine (ACh), respectively, AChE inhibitor and substrate, in an animal model of lipopolysaccharide (LPS)-induced inflammation in Wistar rats. Using intravital microscopy the number of rolling and adherent leukocytes in post-capillary venules was monitorized and blood samples were collected for TNF-α plasma… CONTINUE READING

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