Effects of acetyl salycilic acid and ibuprofen in chronic liver damage induced by CCl4.

@article{Chvez2012EffectsOA,
  title={Effects of acetyl salycilic acid and ibuprofen in chronic liver damage induced by CCl4.},
  author={Enrique Ronald Vidal Ch{\'a}vez and Luis Castro-S{\'a}nchez and Mineko Shibayama and V{\'i}ctor Tsutsumi and Eduardo Perez Salazar and M. Llanos Gil Moreno and Pablo Muriel},
  journal={Journal of applied toxicology : JAT},
  year={2012},
  volume={32 1},
  pages={
          51-9
        }
}
Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs used primarily to treat inflammation, pain and fever. Their main mechanism of action is cyclooxygenase (COX) inhibition, and this enzyme has been linked to hepatotoxicity. The association of COX and liver injury has been, in part, due to the presence of COX-2 isoform in damaged liver and the possible induction of this enzyme by profibrotic molecules like Transforming Growth Factor-β (TGF-β). The aim of this work was to evaluate the… CONTINUE READING
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