Effects of acetaminophen and ibuprofen on renal function in the stressed kidney.

@article{Farquhar1999EffectsOA,
  title={Effects of acetaminophen and ibuprofen on renal function in the stressed kidney.},
  author={William B. Farquhar and Abby L Morgan and Edward J. Zambraski and W. Larry Kenney},
  journal={Journal of applied physiology},
  year={1999},
  volume={86 2},
  pages={598-604}
}
Exercise, salt restriction, and/or dehydration causes transient reductions in renal function that may be buffered by vasodilatory prostaglandins (PGs). Over-the-counter (OTC) analgesics have the potential to alter renal hemodynamics by inhibiting renal PGs. Therefore, we tested the renal effects of the maximal recommended dose of acetaminophen (Acet, 4 g/day) and ibuprofen (Ibu, 1.2 g/day) vs. a placebo (Pl) in humans subjected to progressive renal stresses. After baseline measurements, 12 fit… CONTINUE READING
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