Effects of a synthetic retinoid on skin structure, matrix metalloproteinases, and procollagen in healthy and high-risk subjects with diabetes.

@article{Zeng2011EffectsOA,
  title={Effects of a synthetic retinoid on skin structure, matrix metalloproteinases, and procollagen in healthy and high-risk subjects with diabetes.},
  author={Wei Zeng and Abd A Tahrani and Jayadave Shakher and James Varani and Sharon E Hughes and Kiran Dubb and Martin J. Stevens},
  journal={Journal of diabetes and its complications},
  year={2011},
  volume={25 6},
  pages={398-404}
}
BACKGROUND In diabetes, foot ulceration may result from increased skin fragility. Retinoids can reverse some diabetes-induced deficits of skin structure and function, but their clinical utility is limited by skin irritation. The effects of diabetes and MDI 301, a nonirritating synthetic retinoid, and retinoic acid have been evaluated on matrix metalloproteinases (MMPs), procollagen expression, and skin structure in skin biopsies from nondiabetic volunteers and diabetic subjects at risk of foot… CONTINUE READING