Effects of a synthetic cationic polymer on sodium and potassium currents of frog nerve fibres

@article{Rack1989EffectsOA,
  title={Effects of a synthetic cationic polymer on sodium and potassium currents of frog nerve fibres},
  author={Michael Rack and Gisela Drews},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={1989},
  volume={413},
  pages={610-615}
}
(1) Voltage-clamped nerve fibres of the frogRana esculenta were treated with the synthetic cationic polymer hexadimethrine bromide (HDM) [Polybrene]. (2) 1 μM HDM irreversibly reducedI Na to about 65% of its original size. The time to peak remained almost unaffected, while the decaying phase of the currents (for pulse potentials <− 10 mV) became accelerated… CONTINUE READING