Effects of a stable prostacyclin analogue on platelet activity and on host immunocompetence in mice.

@article{Costantini1990EffectsOA,
  title={Effects of a stable prostacyclin analogue on platelet activity and on host immunocompetence in mice.},
  author={V. Costantini and P. Fuschiotti and A. Giampietri and M. Allegrucci and G. Agnelli and G. Nenci and M. Fioretti},
  journal={Prostaglandins},
  year={1990},
  volume={39 6},
  pages={
          581-99
        }
}
  • V. Costantini, P. Fuschiotti, +4 authors M. Fioretti
  • Published 1990
  • Biology, Medicine
  • Prostaglandins
  • The stable prostacyclin (PGI2) analogue, iloprost, is a potent inhibitor of both tumor cell-induced platelet aggregation and of experimental metastasis in mice. To explore possible mechanisms of antimetastatic effect of iloprost, we measured the effect of this drug on both platelet aggregation and immunocompetence in the mouse. Iloprost (4 x 10(-8) M) inhibited platelet aggregation as induced by a mixture of collagen and epinephrine for at least 180 minutes of incubation, and completely… CONTINUE READING
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