Effects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure: comparison of effects with those of endothelin A receptor antagonism.

@article{Wada1999EffectsOA,
  title={Effects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure: comparison of effects with those of endothelin A receptor antagonism.},
  author={Atsuyuki Wada and Takayoshi Tsutamoto and Masato Ohnishi and Masahide Sawaki and Daisuke Fukai and Yuka Maeda and Masahiko Kinoshita},
  journal={Circulation},
  year={1999},
  volume={99 4},
  pages={570-7}
}
BACKGROUND--Endothelin (ET)-1 is generated from big ET-1 by endothelin-converting enzyme (ECE). Plasma big ET-1 and ET-1 levels are strongly related to survival in patents with congestive heart failure (CHF). Because selective enzymatic processing of ET-1 formation appears to be an important therapeutic target for CHF, we investigated the acute effects of a… CONTINUE READING