Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers.


1. Sparfloxacin, a new fluoroquinolone, slightly increases the duration of the QT interval. Reverse rate-dependence of QT interval prolongation has been shown for many agents that are known to prolong QT interval duration, and QT prolongation at slow heart rates may be a risk factor for torsades de pointes. 2. A double-blind, randomized, placebo controlled… (More)


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