Effects of a single oral dose of desipramine on postoperative morphine analgesia.

@article{Max1992EffectsOA,
  title={Effects of a single oral dose of desipramine on postoperative morphine analgesia.},
  author={Mitchell B. Max and Dominique de Zeigler and Susan Elizabeth Shoaf and Edward Craig and James Benjamin and Shu Hong Li and C A Buzzanell and Margarita P{\'e}rez and Bimal C. Ghosh},
  journal={Journal of pain and symptom management},
  year={1992},
  volume={7 8},
  pages={454-62}
}
Drugs that block norepinephrine reuptake offer promise as opioid potentiators, because norepinephrine mediates opioid analgesia but not side effects such as sedation or nausea. In a two-by-two factorial design, we randomized 62 inpatients with pain following major surgery to receive either desipramine, 50 mg by mouth, or placebo at 6 a.m. on the first day after surgery. At their first request of pain medication after 8 a.m., they were given intravenous morphine, either 0.033 mg/kg or 0.10 mg/kg… CONTINUE READING
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