Effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat.

@article{Brawer1978EffectsOA,
  title={Effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat.},
  author={James Brawer and Frederick Naftolin and J -C. Martin and Carlos Sonnenschein},
  journal={Endocrinology},
  year={1978},
  volume={103 2},
  pages={501-12}
}
Young adult cyclic female rats were each injected with 2 mg estradiol valerate (EV) in sesame oil. Controls received an equivalent volume of sesame oil. Within 2 months after injection, most of the EV-treated animals showed persistent vaginal estrus and small polyfollicular ovaries as well as pathological changes in the hypothalamic arcuate nucleus. This… CONTINUE READING