Effects of a selective cyclooxygenase-2 inhibitor on postoperative inflammatory reaction and pain after total knee replacement.

@article{Feng2008EffectsOA,
  title={Effects of a selective cyclooxygenase-2 inhibitor on postoperative inflammatory reaction and pain after total knee replacement.},
  author={Yi Feng and Hui Ju and Baxian Yang and Haiyan An},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2008},
  volume={9 1},
  pages={45-52}
}
UNLABELLED The goal of this study was to evaluate the systemic and peripheral effects of preoperative administration of cyclooxygenase-2 inhibitor on pain and inflammation occurring with total knee replacement (TKR). Patients undergoing elective TKR were prospectively and randomly given oral rofecoxib (25 mg) or placebo (control group) 1 hour before surgery. All patients received an epidural combined with isoflurane anesthesia during the operation and patient-controlled epidural analgesia… CONTINUE READING