Effects of a selective alpha 2-adrenoceptor antagonist, atipamezole, on hypothalamic histamine and noradrenaline release in vivo.

@article{Laitinen1995EffectsOA,
  title={Effects of a selective alpha 2-adrenoceptor antagonist, atipamezole, on hypothalamic histamine and noradrenaline release in vivo.},
  author={Kirsti S. M. Laitinen and Leena M Tuomisto and E. Macdonald},
  journal={European journal of pharmacology},
  year={1995},
  volume={285 3},
  pages={255-60}
}
In vivo microdialysis was used to study the effects of a potent and selective alpha 2-adrenoceptor antagonist, atipamezole, on histamine and noradrenaline release from the medial hypothalamus in anesthetized rats. Local perfusion with atipamezole via the microdialysis probe increased histamine release significantly and dose-dependently. However, the effect… CONTINUE READING