Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression

  title={Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression},
  author={Ewa Tatarczyńska and Aleksandra Kłodzińska and Katarzyna Stachowicz and E. Chojnacka-w{\'o}jcik},
  journal={Behavioural Pharmacology},
The purpose of the present study was to investigate the effects of the selective 5-HT1B receptor agonist CP 94253, the selective 5-HT1B receptor antagonist SB 216641, and the 5-HT1B/1D receptor antagonist GR 127935 in behavioral tests commonly used to predict anxiolytic- and antidepressant-like activity. Diazepam and imipramine were used as reference drugs. In the Vogel conflict drinking test, CP 94253 (1.25–5 mg/kg), SB 216641 (2.5–5 mg/kg) and GR 127935 (5–10 mg/kg) showed anxiolytic-like… 

Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats

The results obtained indicate that the hippocampus is one of the neuroanatomical sites involved in the anxiolytic-like and antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-258585.

S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

5-HT1B receptor activation during testing appears to be critical for S-ketamine’s antidepressant-like potentials in this model, suggesting that the observed behavioral interaction could not be ascribed to a kinetic drug-drug interaction.

Implication of 5-HT2B receptors in the serotonin syndrome

Blockade of 5-HT1A Receptors by (±)-Pindolol Potentiates Cortical 5-HT Outflow, but not Antidepressant-Like Activity of Paroxetine: Microdialysis and Behavioral Approaches in 5-HT1A Receptor Knockout Mice

It is confirmed that (±)-pindolol behaves as an antagonist of 5-HT1A autoreceptor in mice, but its blockade of paroxetine-induced antidepressant-like effects in the FST may be due to its binding to other neurotransmitter receptors.

The role of 5-HT1A and 5-HT1B receptors in MDMA self-administration

MDMA-stimulated serotonin (5-HT) release was negatively associated with acquisition of MDMA self-administration, and a neurotoxic 5-HT lesion reduced the latency to acquire self- Administration, suggesting that MDMA-produced 5- HT release is an important component of self-Administration.



The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test

It is postulate that only 5-HT2A receptors play a pivotal role in the effects of SSRIs in this model of anxiety.

Modification of the Anxiolytic Action of 5-HT1A Compounds by GABA–Benzodiazepine Agents in Rats

Effects of combined administration of 5-HT1A and/or 5-HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats.

The obtained results seem to indicate that blockade of 5- HT1B receptors, but not 5-HT1A ones, can facilitate the antidepressant-like effect of paroxetine in the forced swimming test in rats.

Interaction of GABA and serotonin in the anxiolytic action of diazepam and serotonergic anxiolytics

Anxiogenic-like effect of serotonin1B receptor stimulation in the rat elevated plus-maze

5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253

Findings imply that 5-HT1B receptors regulate discrete elements of satiety and the potential role of 5- HT1B agonists for the treatment of obesity is discussed.

Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice.

The results suggest that 5-HT(1A) and 5- HT(1B) receptors have different roles in the modulation of the response to antidepressant drugs in the TST, suggesting mediation by enhanced catecholamine function.

CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon

Results suggest that CP-135,807 produces centrally mediated psychoactive effects that differ distinctly from those of 5-HT1A agonists.