Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression

@article{Tatarczyska2004EffectsOA,
  title={Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression},
  author={Ewa Tatarczyńska and Aleksandra Kłodzińska and Katarzyna Stachowicz and E. Chojnacka-w{\'o}jcik},
  journal={Behavioural Pharmacology},
  year={2004},
  volume={15},
  pages={523-534}
}
The purpose of the present study was to investigate the effects of the selective 5-HT1B receptor agonist CP 94253, the selective 5-HT1B receptor antagonist SB 216641, and the 5-HT1B/1D receptor antagonist GR 127935 in behavioral tests commonly used to predict anxiolytic- and antidepressant-like activity. Diazepam and imipramine were used as reference drugs. In the Vogel conflict drinking test, CP 94253 (1.25–5 mg/kg), SB 216641 (2.5–5 mg/kg) and GR 127935 (5–10 mg/kg) showed anxiolytic-like… 

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