Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving.

@article{Tashiro2008EffectsOA,
  title={Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving.},
  author={Manabu Tashiro and Yumiko Sakurada and Hideki Mochizuki and Etsuo Horikawa and Masahiro Maruyama and Nobuyuki Okamura and Shoichi Watanuki and Hiroyuki Arai and Masatoshi Itoh and Kazuhiko Yanai},
  journal={Human psychopharmacology},
  year={2008},
  volume={23 2},
  pages={139-50}
}
OBJECTIVES The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated car-driving task following oral administration of D-chlorpheniramine using positron emission tomography (PET) and [15O]H2O, based on a single-blind cross-over study-design. METHODS Right… CONTINUE READING
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