Effects of a purported aromatase and 5α-reductase inhibitor on hormone profiles in college-age men.

@article{Wilborn2010EffectsOA,
  title={Effects of a purported aromatase and 5$\alpha$-reductase inhibitor on hormone profiles in college-age men.},
  author={Colin Wilborn and L. Taylor and C. Poole and Cliffa A. Foster and D. Willoughby and R. Kreider},
  journal={International journal of sport nutrition and exercise metabolism},
  year={2010},
  volume={20 6},
  pages={
          457-65
        }
}
The purpose of this study was to determine the effects of an alleged aromatase and 5-α reductase inhibitor (AI) on strength, body composition, and hormonal profiles in resistance-trained men. Thirty resistance-trained men were randomly assigned in a double-blind manner to ingest 500 mg of either a placebo (PL) or AI once per day for 8 wk. Participants participated in a 4-d/wk resistance-training program for 8 wk. At Weeks 0, 4, and 8, body composition, 1-repetition-maximum (1RM) bench press and… Expand
Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review.
TLDR
The main findings of this review indicate that 2 herbal extracts, fenugreek seed extracts and ashwagandha root and root/leaf extracts, have positive effects on testosterone concentrations in men, and some evidence exists for another herb and herbal extract, Asian red ginseng and forskohlii root extract. Expand
The Effects of a Multi-Ingredient Performance Supplement on Hormonal Profiles and Body Composition in Male College Athletes
TLDR
Findings suggest the MIPS can prevent decrements in LBM and anabolic hormone profiles during intense training periods, and suggest this supplement should be used in conjunction with resistance training and specialized sports training. Expand
Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study
TLDR
Fenu-FG supplementation showed beneficial effects in male subjects during resistance training without any clinical side effects and was found to be safe and well-tolerated. Expand
Consumption of a Testosterone-Boosting Supplement Is Safe and Lowers Estrogen and Cortisol Levels: 1285 Board #78 May 28, 9
TLDR
The findings of this study suggest that N-Acetylcysteine supplementation of 70mg/kgbtw has no effect on repeat sprint performance, specifically mean sprint time, peak Sprint time, and fatigue index. Expand
EFFECTS OF GLYCOSIDES BASED FENUGREEK SEED EXTRACT ON SERUM TESTOSTERONE LEVELS OF HEALTHY SEDENTARY MALE SUBJECTS: A EXPLORATORY DOUBLE BLIND, PLACEBO CONTROLLED, CROSSOVER STUDY
TLDR
Acute administration ofIND9 capsule supplementation to sedentary males showed potential androgenic benefits with good safety profile and the supplementation of IND9 and placebo was found to be safe and well-tolerated. Expand
Links Between Testosterone, Oestrogen, and the Growth Hormone/Insulin-Like Growth Factor Axis and Resistance Exercise Muscle Adaptations
TLDR
Evidence is presented on the importance of testosterone, estrogen, and other hormones in the regulation of skeletal muscle mass and their responses, and involvement in muscle adaptation to resistance exercise, and the downstream mechanisms by which these hormones impact regulation of muscle protein turnover, and thus muscle mass are discussed. Expand
Pulmonary Embolism Secondary to Testosterone-Enhancing Herbal Supplement Use
TLDR
A patient is presented with new-onset, bilateral pulmonary embolism possibly associated with the daily use of fenugreek-containing testosterone supplements, a common active ingredient in commercially available herbal supplements that are often marketed as testosterone enhancers. Expand
Oral Testofen, L-Citrulline, Resveratrol, and Caffeine Supplement Drink Improves Sexual Function in Men with Phosphodiesterase 5 Inhibitors: Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study.
TLDR
This is the first study to show that the supplement drink created may not only be effective for erection but also for libido, orgasm, and ejaculation. Expand
The Aging Male Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen..
This study examined the effect of Testofen, a specialised Trigonella foenum-graecum seed extract on the symptoms of possible androgen deficiency, sexual function and serum androgen concentrations inExpand
Efficacy and Safety of a Mixed Extract of Trigonella foenum-graecum Seed and Lespedeza cuneata in the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
TLDR
The mixed extract of TFGL resulted in significant improvements in symptoms of TDS, as measured by the AMS, ADAM, PSS-10 and testosterone levels. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 31 REFERENCES
Eight weeks of aromatase inhibition using the nutritional supplement Novedex XT: effects in young, eugonadal men.
TLDR
Novedex XT significantly increases serum androgen levels and decreases fat mass, and no significant differences were observed in blood and urinary clinical safety markers or for any of the other serum hormones. Expand
Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males
TLDR
While neither of the 6-OXO dosages appears to have any negative effects on clinical chemistry markers, supplementation at a daily dosage of 300 mg and 600 mg for eight weeks did not completely inhibit aromatase activity, yet significantly increased FT, DHT, and T/E. Expand
The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men.
TLDR
It is concluded that aromatase inhibition can reduce estrogen levels in older men, but this effect is limited, perhaps because of feedback stimulation of testosterone production, and that endogenous estrogen derived from aromatization of testosterone plays a role in bone metabolism of older men by limiting the rate of bone resorption. Expand
Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men.
TLDR
Examination of the effects of androgen precursors, combined with herbal extracts designed to enhance testosterone formation and reduce conversion of androgens to estrogens was studied in young men to provide evidence that the addition of these herbal extracts to androstenedione does not result in increased serum testosterone concentrations, reduce the estrogenic effect of androstensione, and does not augment the adaptations to resistance training. Expand
Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels.
TLDR
It is demonstrated that aromatase inhibition increases serum bioavailable and total testosterone levels to the youthful normal range in older men with mild hypogonadism. Expand
Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males.
TLDR
Exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors and long-term efficacy and safety will need further study. Expand
Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men.
TLDR
DHEA ingestion does not enhance serum testosterone concentrations or adaptations associated with resistance training in young men, and serum androstenedione concentrations increased significantly and similarly in the men treated with placebo and DHEA. Expand
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.
TLDR
Supraphysiologic doses of testosterone, especially when combined with strength training, increase fat-free mass and muscle size and strength in normal men. Expand
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.
TLDR
Those given testosterone had greater increases than those given placebo in muscle size in their arms and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively. Expand
Acute hormonal response to sublingual androstenediol intake in young men.
TLDR
Assessment of the acute hormonal response to sublingual cyclodextrin androstenediol supplement in young men in a randomized, double-blind, crossover manner indicates that sublingually cyclodeXTrin and Frostenediol intake increases serum androsthenione, free testosterone, total testosterone, and estradiol concentrations. Expand
...
1
2
3
4
...