Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men.

@article{Jaffe1993EffectsOA,
  title={Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men.},
  author={Craig A. Jaffe and Phoebe Ho and Roberta Demott-Friberg and Cyril Y. Bowers and Ariel L Barkan},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1993},
  volume={77 6},
  pages={
          1641-7
        }
}
Bolus injection of the synthetic hexapeptide GH-releasing peptide-6 (GHRP-6) reliably promotes GH secretion. However, desensitization to the GH-releasing effects of GHRP has been shown to occur during short term iv infusion. To determine whether humans would remain responsive to prolonged exposure to GHRP and to study the mechanism of action of GHRP, we compared the effects of a 34-h iv infusion of either GHRP or normal saline on parameters of pulsatile GH concentration in nine healthy young… CONTINUE READING
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