Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials.

@article{Nissen2007EffectsOA,
  title={Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials.},
  author={Steven Evan Nissen and Stephen J Nicholls and Kathy E Wolski and Daniel C. Howey and Ellen S McErlean and Ming-Dauh Wang and Elisa V Gomez and John M Russo},
  journal={JAMA},
  year={2007},
  volume={297 12},
  pages={1362-73}
}
CONTEXT Fibrates are weak agonists of peroxisome proliferator-activated receptor alpha (PPAR-alpha). No trials have reported effects of more potent and selective agents. OBJECTIVES To examine the safety and efficacy of LY518674, a PPAR-alpha agonist. DESIGN, SETTING, AND PARTICIPANTS Two multicenter, randomized, double-blind, placebo-controlled trials: 1 in patients with elevated triglycerides and low HDL-C (atherogenic dyslipidemia), the other in patients with elevated LDL-C… CONTINUE READING

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