Effects of a nitric oxide synthase inhibitor in humans with septic shock.

@article{Petros1994EffectsOA,
  title={Effects of a nitric oxide synthase inhibitor in humans with septic shock.},
  author={A. J. Petros and Gabrielle Lamb and Anna Leone and Salvador Moncada and David Bennett and Patrick J. T. Vallance},
  journal={Cardiovascular research},
  year={1994},
  volume={28 1},
  pages={34-9}
}
OBJECTIVE Studies in animals have indicated that increased production of nitric oxide from an inducible isoform of nitric oxide synthase contributes to the pathophysiology of endotoxic and cytokine induced shock. The aim of this study was to determine the role of nitric oxide in septic shock in humans. METHODS The study was a randomised, double blind, placebo controlled investigation of the effects of the nitric oxide synthase inhibitor NG monomethyl-L-arginine (L-NMMA) in 12 patients with… CONTINUE READING
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