Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.

@article{Lonce1992EffectsOA,
  title={Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.},
  author={St{\'e}phane L{\'e}once and Alain Pierre and Monique Anstett and Valerie S. Perez and Annie Genton and Jean Pierre Bizzari and Ghanen Atassi},
  journal={Biochemical pharmacology},
  year={1992},
  volume={44 9},
  pages={
          1707-15
        }
}
A new triazinoaminopiperidine derivative, Servier 9788 (S9788), was investigated for its ability to increase Adriamycin (ADR) accumulation and retention in two rodent (P388/ADR and DC-3F/AD) and three human (KB-A1, K562/R and COLO 320DM) cell lines displaying the P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) phenotype. Depending on the cell line S9788 was shown to be two to five times more active and five to 15 times more potent than Verapamil (VRP) in increasing ADR accumulation in… CONTINUE READING
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