Effects of a new cholinolytic drug of tropanes and its optical isomers on central muscarinic and nicotinic receptors.

Abstract

2 alpha-(2',2'-disubstituted-2'-hydroxy-ethoxy)tropane (2 alpha-DHET cholinolytic, is a racemic tertiary amine with two chiral carbonic atoms. It has four optical isomers whose absolute configurations are 1R-2 alpha-2'S, 1R-2 alpha-2'R 1S-2 alpha'R and 1S-2 alpha-2'S. These compounds showed both antimuscarinic and antinicotinic activity, blocking both… (More)

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Cite this paper

@article{Gao1995EffectsOA, title={Effects of a new cholinolytic drug of tropanes and its optical isomers on central muscarinic and nicotinic receptors.}, author={Zhan-guo Gao and Li-dong Wang and C. G. Liu and Qinghai Zhang}, journal={Pharmacological research}, year={1995}, volume={32 3}, pages={105-9} }