Effects of a new TRH analogue, YM-14673 on the central nervous system

@article{Yamamoto1987EffectsOA,
  title={Effects of a new TRH analogue, YM-14673 on the central nervous system},
  author={Minoru Yamamoto and Masao Shimizu},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1987},
  volume={336},
  pages={561-565}
}
The effects of a new TRH analogue, YM-14673 (Nα-[{(S)-4-oxo-2-azetidinyl}carbonyl]-L-histidyl-L-prolinamide dihydrate) on the central nervous system were compared with those of TRH. YM-14673 was 10–40 times more potent than TRH in antagonizing pentobarbital-induced sleep and hypothermia, and ethanol-induced hypothermia in mice. YM-14673 accelerated recovery… CONTINUE READING