Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats.

  title={Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats.},
  author={Naoki Kojima and Jan Michael Williams and Teisuke Takahashi and Noriyuki Miyata and Richard J. Roman},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={345 3},
This study examined the effect of long-term control of hyperglycemia with a new sodium glucose cotransporter 2 inhibitor, luseogliflozin, given alone or in combination with lisinopril on the progression of renal injury in the T2DN rat model of type 2 diabetic nephropathy. Chronic treatment with luseogliflozin (10 mg/kg/day) produced a sustained increase in glucose excretion and normalized blood glucose and glycosylated hemoglobin levels to the same level as seen in the rats treated with insulin… CONTINUE READING
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