Effects of a natural extract of (–)‐hydroxycitric acid (HCA‐SX) and a combination of HCA‐SX plus niacin‐bound chromium and Gymnema sylvestre extract on weight loss

@article{Preuss2004EffectsOA,
  title={Effects of a natural extract of (–)‐hydroxycitric acid (HCA‐SX) and a combination of HCA‐SX plus niacin‐bound chromium and Gymnema sylvestre extract on weight loss},
  author={Harry G Preuss and Debasis Bagchi and Manashi Bagchi and Chava Venkata Nageswara Rao and Debalina Dey and S Satyanarayana},
  journal={Diabetes},
  year={2004},
  volume={6}
}
AIM The efficacy of optimal doses of highly bioavailable (-)-hydroxycitric acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites. [...] Key Method Subjects were randomly divided into three groups.Expand
An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management.
TLDR
Clinical studies demonstrate the safety, bioavailability and efficacy of HCA-SX in weight management and show concentration-dependent release of serotonin in isolated rat brain cortex, which may explain its appetite suppressive action. Expand
Safety of a Novel Calcium/Potassium Salt of Hydroxycitric Acid (HCA-SX): I. Two-Generation Reproduction Toxicity Study
TLDR
Dietary exposure of HCA-SX to parental male and female rats of both sexes during the premating and mating periods, for both sexes, and during gestation and lactation in case of female rats, did not reveal any remarkable incidence of mortality or abnormal clinical signs. Expand
(‐)‐Hydroxycitric Acid Nourishes Protein Synthesis via Altering Metabolic Directions of Amino Acids in Male Rats
TLDR
Investigation of the effects of long‐term supplement with HCA on body weight gain and variances of amino acid content in rats indicated that (‐)‐HCA treatment could reduce body weight Gain through promoting energy expenditure via regulation of thyroid hormone levels and promote protein synthesis by altering the metabolic directions of amino acids. Expand
Safety assessment of a calcium-potassium salt of (−)-hydroxycitric acid
TLDR
The consumption of HCA-SX at dose level of up to 4667 mg/day is considered safe and there were no macroscopic abnormalities for any examined tissues at scheduled necropsies. Expand
EFFECT OF NATURAL EXTRACT OF HYDROXYCITRIC ACID ON LIPID PROFILE, LIVER AND TESTES OF ADULT MALE RATS
TLDR
The effect of GC/HCA on body weight and lipid profile is dose and duration dependent and higher dose is more effective in reducing TBW and LDL/HDL ratio. Expand
Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt.
TLDR
There is sufficient qualitative and quantitative scientific evidence, including animal and human data suggesting that intake of HCA at levels up to 2800 mg/day is safe for human consumption, and the structure, mechanism of action, long history of use and other toxicity studies indicate that HCA-SX is unlikely to cause reproductive or developmental effects. Expand
Safety Assessment of a Novel Niacin-Bound Chromium-Based Energy Formulation
TLDR
The safety of a novel niacin-bound chromium-based Energy Formulation, which also contained caffeine, D-ribose, Withania somnifera extract, and selected amino acids is demonstrated. Expand
Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid.
TLDR
HCA-SX has been shown to increase serotonin availability, reduce appetite, increase fat oxidation, improve blood lipid levels, reduce body weight, and modulate a number of obesity regulatory genes without affecting the mitochondrial and nuclear proteins required for normal biochemical and physiological functions. Expand
Updates on Antiobesity Effect of Garcinia Origin (−)-HCA
TLDR
This review was prepared to summarise the update of chemical constituents, significance of in vivo/clinical anti-obesity effects, and the importance of the current market potential of Garcinia/hydroxycitric acid. Expand
Safety of a Novel Calcium/Potassium Saltof (-)-Hydroxycitric Acid (HCA-SX): II.Developmental Toxicity Study in Rats
TLDR
HCA-SX was not found to be teratogenic in the Sprague-Dawley rat at the dietary exposure levels of 1000, 3000, and 10,000 ppm, equivalent to the dose levels of 103, 352, or 1240 mg/kg/day, respectively. Expand
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HCA-SX can inhibit [3H]-5-HT uptake (and also increase 5-HT availability) in isolated rat brain cortical slices in a manner similar to that of SRRIs, and thus may prove beneficial in controlling appetite, as well as treatment of depression, insomnia, migraine headaches and other serotonin-deficient conditions. Expand
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