Effects of a hydroxyl radical scavenger on delayed ischemic neurological deficits following aneurysmal subarachnoid hemorrhage: results of a multicenter, placebo-controlled double-blind trial.

@article{Asano1996EffectsOA,
  title={Effects of a hydroxyl radical scavenger on delayed ischemic neurological deficits following aneurysmal subarachnoid hemorrhage: results of a multicenter, placebo-controlled double-blind trial.},
  author={Tomohiko Asano and Kintomo Takakura and Katsutoshi Sano and Hiroyoshi Kikuchi and Hiroyuki Nagoya Nagai and Ichiro Saito and Akira Tamura and Chikayuki Ochiai and Tombo Sasaki},
  journal={Journal of neurosurgery},
  year={1996},
  volume={84 5},
  pages={
          792-803
        }
}
A water-soluble, novel synthetic compound, AVS ((+/-)-N, N'-propylenedinicotinamide; nicaraven) has no demonstrable vasoactive properties but scavenges hydroxyl radicals in aqueous environmental conditions at neutral pH. Based on the results of preceding experimental and clinical studies showing marked ameliorative effects of AVS on cerebral vasospasm and ischemic brain damage, a multicenter, placebo-controlled double-blind clinical trial was undertaken to verify its beneficial effects on… CONTINUE READING
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Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage

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