Effects of a histamine type-2 receptor antagonist (BMY-25368) on gastric secretion in horses.

@article{Orsini1991EffectsOA,
  title={Effects of a histamine type-2 receptor antagonist (BMY-25368) on gastric secretion in horses.},
  author={James A. Orsini and D J Dreyfuss and J J Vecchione and Pamela A Spencer and R Uhlman},
  journal={American journal of veterinary research},
  year={1991},
  volume={52 1},
  pages={108-10}
}
The effects of a potent new histamine-2 (H2) receptor antagonist, BMY-25368, were studied on gastric acid secretion in 5 foals from which food was withheld. Doses of 0.02, 0.11, 0.22, and 1.10 mg/kg of body weight were administered IM in a randomly assigned treatment sequence. Following BMY-25368 administration, hydrogen ion concentration was decreased and mean pH was higher than baseline values in a dose-response pattern. At the 0.22 and 1.10 mg/kg doses, the high pH was sustained for greater… CONTINUE READING