Effects of a hexokinase II deletion on the dynamics of glycolysis in continuous cultures of Saccharomyces cerevisiae.

@article{Diderich2002EffectsOA,
  title={Effects of a hexokinase II deletion on the dynamics of glycolysis in continuous cultures of Saccharomyces cerevisiae.},
  author={Jasper A. Diderich and L{\'e}onie M. Raamsdonk and Arthur Kuiper and Arthur L. Kruckeberg and Jan A. Berden and Maarten Joost Teixeira de Mattos and Karel van Dam},
  journal={FEMS yeast research},
  year={2002},
  volume={2 2},
  pages={165-72}
}
In glucose-limited aerobic chemostat cultures of a wild-type Saccharomyces cerevisiae and a derived hxk2 null strain, metabolic fluxes were identical. However, the concentrations of intracellular metabolites, especially fructose 1,6-bisphosphate, and hexose-phosphorylating activities differed. Interestingly, the hxk2 null strain showed a higher maximal growth rate and higher Crabtree threshold dilution rate, revealing a higher oxidative capacity for this strain. After a pulse of glucose… CONTINUE READING
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