Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects

  title={Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects},
  author={Giada De Palma and Inmaculada Nadal and Mar{\'i}a Carmen Collado and Yolanda Sanz},
  journal={British Journal of Nutrition},
  pages={1154 - 1160}
Diet influences the composition of the gut microbiota and host's health, particularly in patients suffering from food-related diseases. Coeliac disease (CD) is a permanent intolerance to cereal gluten proteins and the only therapy for the patients is to adhere to a life-long gluten-free diet (GFD). In the present preliminary study, the effects of a GFD on the composition and immune function of the gut microbiota were analysed in ten healthy subjects (mean age 30·3 years) over 1 month. Faecal… 

Effects of a gluten-free diet on gut microbiota and immune function in healthy adult humans

Fecal samples of subjects under a GFD, which represent an altered microbiota, also exerted lower immune stimulatory effects on peripheral blood mononuclear cells than those of subjects on a regular gluten-containing diet.

The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others

The biomedical community is persuaded to think that the results from the effect of GFD on health and the gut microbiota cannot be extrapolated from one population to others, and encourages the conception of more collaborative efforts to study local populations in an effort to reach biologically and medically useful conclusions that truly contribute to improve health in patients afflicted with GRD.

Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients

Evidence regarding the use of prebiotics and probiotics in patients with CD is still insufficient to justify their use in clinical practice, but the inclusion of preBiotics in GFD could also be easy to administer and cost-effective as an adjunctive treatment for CD.

The influence of a short-term gluten-free diet on the human gut microbiome

A GFD changes the gut microbiome composition and alters the activity of microbial pathways and observes strong relations between the predicted activity of pathways and biomarker measurements.

Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota

Investigations are needed to fill the gaps in knowledge concerning the associations between the gut microbiome, environmental exposures, epigenetics, racial influences, and the propensity for immune dysregulation with its inherent risk to the developing individual.

Faecal Concentrations of Short-chain Fatty Acids and Selected Bacteria in Healthy and Celiac Children

Changes in microbiota and SCFAs are clearly related to the pathogenesis of CD, as being potential pro-inflammatory agents in CD, acetic and propionic acid may serve as important disease-related markers.

Dietary Gluten-Induced Gut Dysbiosis Is Accompanied by Selective Upregulation of microRNAs with Intestinal Tight Junction and Bacteria-Binding Motifs in Rhesus Macaque Model of Celiac Disease

It is predicted that with the introduction of effective treatments in future studies the diversity of gut microbiomes in GS macaques will approach those of healthy individuals.

Salivary and fecal microbiota and metabolome of celiac children under gluten-free diet.

The Modification of the Gut Microbiota via Selected Specific Diets in Patients with Crohn’s Disease

The impact of diet interventions on the microbiota and, potentially, on the future course of the disease should be considered when nutritional guidelines for IBD patients are designed.



Imbalance in the composition of the duodenal microbiota of children with coeliac disease.

The higher incidence of Gram-negative and potentially pro-inflammatory bacteria in the duodenal microbiota of coeliac children was linked to the symptomatic presentation of the disease and could favour the pathological process of the disorder.

Differences between the fecal microbiota of coeliac infants and healthy controls.

The bacterial pattern detected in coeliac patients, correlates with the epidemiological data and metabolic deviations associated with CD, and involve bacterial groups link to other chronic inflammatory disorders.

Metabolic and Nutritional Features in Adult Celiac Patients

Weight loss and nutritional deficiencies are relevant clinical features in CD and an early and accurate evaluation of nutritional status and energy metabolism represents a fundamental tool in the management of CD patients.

Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease

Duodenal and faecal microbiota is unbalanced in children with untreated coeliac disease and only partially restored after long-term treatment with a GFD, constituting a novel factor linked to this disorder.

Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications

The results suggest that despite sharing certain features, some strains can perform a better functional role than others and their careful selection for therapeutic use is desirable.

A dietary survey to determine if patients with coeliac disease are meeting current healthy eating guidelines and how their diet compares to that of the British general population

Patients with coeliac disease are at risk of having an inadequate intake of calcium, NSP and vitamin D, and Specialist GFP, which were obtained on prescription, helped patients get a balanced diet and without these patients would be at an increased risk of many deficiencies.

Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet.

  • J. CosnesC. Cellier I. Nion‐Larmurier
  • Medicine, Biology
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2008

Gaining insight into microbial physiology in the large intestine: a special role for stable isotopes.

Active Crohn's disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora

The fecal flora is highly structured and spatially organized and Diagnosing IBD and monitoring disease activity can be performed based on analysis of punched fecal cylinders independent from the patient's complaints.