Effects of a fragment of human growth hormone-releasing factor in normal and 'Little' mice.

@article{Clark1985EffectsOA,
  title={Effects of a fragment of human growth hormone-releasing factor in normal and 'Little' mice.},
  author={Ross G. Clark and I C Robinson},
  journal={The Journal of endocrinology},
  year={1985},
  volume={106 1},
  pages={
          1-5
        }
}
The 'Little' mouse is characterized by a body growth rate 60% of normal due to a defect in the synthesis and storage of GH in the anterior pituitary gland. We have now investigated the effects of GH releasing factor (GRF) in these mice and in normal animals. The pituitary GH content in Little mice was only 4% of that in normal C57: +/+ mice, and was not affected by twice daily i.p. injections of human (h) GRF1-29NH2 (0.2-2 micrograms) for 14 days. This treatment also had no effect on body… Expand
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