Effects of a d-Xylose Preload With or Without Sitagliptin on Gastric Emptying, Glucagon-Like Peptide-1, and Postprandial Glycemia in Type 2 Diabetes

@inproceedings{Wu2013EffectsOA,
  title={Effects of a d-Xylose Preload With or Without Sitagliptin on Gastric Emptying, Glucagon-Like Peptide-1, and Postprandial Glycemia in Type 2 Diabetes},
  author={Tongzhi Wu and Michelle J. Bound and Beiyi R. Zhao and Scott D. Standfield and Max S Bellon and Karen L Jones and Michael Horowitz and Christopher K Rayner},
  booktitle={Diabetes care},
  year={2013}
}
OBJECTIVE Macronutrient "preloads" can reduce postprandial glycemia by slowing gastric emptying and stimulating glucagon-like peptide-1 (GLP-1) secretion. An ideal preload would entail minimal additional energy intake and might be optimized by concurrent inhibition of dipeptidyl peptidase-4 (DPP-4). We evaluated the effects of a low-energy D-xylose preload, with or without sitagliptin, on gastric emptying, plasma intact GLP-1 concentrations, and postprandial glycemia in type 2 diabetes… CONTINUE READING
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