Effects of a cyclo-oxygenase inhibitor, flurbiprofen, and an H1 histamine receptor antagonist, terfenadine, alone and in combination on allergen induced immediate bronchoconstriction in man.

@article{Curzen1987EffectsOA,
  title={Effects of a cyclo-oxygenase inhibitor, flurbiprofen, and an H1 histamine receptor antagonist, terfenadine, alone and in combination on allergen induced immediate bronchoconstriction in man.},
  author={Nick Curzen and Paul Rafferty and Stephen T. Holgate},
  journal={Thorax},
  year={1987},
  volume={42 12},
  pages={946-52}
}
The effect of flurbiprofen, a potent cyclo-oxygenase inhibitor, on histamine and methacholine reactivity was assessed in seven atopic subjects with asthma. Flurbiprofen 150 mg daily for three days displaced the histamine-FEV1 concentration-response curve to the right by 1.5 doubling doses, whereas no effect was observed on the response to methacholine. Subsequently the effects of flurbiprofen and terfenadine, a specific H1 histamine receptor antagonist, on allergen induced bronchoconstriction… CONTINUE READING

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The inhibitory effect of terfenadine on bronchoconstriction induced by adenosine monophosphate and allergen [ abstract ]

  • P Rafferty, CR Beasley, ST Holgate
  • Thorax
  • 1986

Lung function and plasma levels of thromboxane B 2 , 6 - ketoprostaglandin F , and fi - thromboglobulin in antigen - induced asthma before and after indomethacin pretreatment

  • EG Shepard, L Malan, CM Macfarlane, W Mouton, Joubert
  • Br J Clin Phar - macol
  • 1985

Non - steroidal anti - inflammatory drugs in asthma : angerous or useful therapy ?

  • Joubert, E Shephard, W Mouton, L VanZyl, I Viljoen
  • Allergy
  • 1985

Release of histamine and newly generated mediators from human bronchoalveolar lavage cells [ abstract ]

  • RM Agius, C Robinson, ST Holgate
  • Thorax
  • 1985

The central role of cyclooxygenase products in the response of the canine peripheral lung to antigen aerosol [ abstract ]

  • Kleeberger, J Kolbe, SP Peters, EW Spannihake
  • Fed Proc
  • 1985

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