Effects of a cardiomyopathy-causing troponin t mutation on thin filament function and structure.

@article{Burhop2001EffectsOA,
  title={Effects of a cardiomyopathy-causing troponin t mutation on thin filament function and structure.},
  author={J W Burhop and Michael Rosol and Roger Craig and Larry S. Tobacman and William Lehman},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 23},
  pages={20788-94}
}
Familial hypertrophic cardiomyopathy (FHC) is caused by missense or premature truncation mutations in proteins of the cardiac contractile apparatus. Mutant proteins are incorporated into the thin filament or thick filament and eventually produce cardiomyopathy. However, it has been unclear how the several, genetically identified defects in protein structure translate into impaired protein and muscle function. We have studied the basis of FHC caused by premature truncation of the most frequently… CONTINUE READING

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