Effects of a bisphosphonate (1-hydroxy ethylidene-1,1 bisphosphonic acid) on osteoclast number during prolonged bed rest in healthy humans.

@article{Chappard1989EffectsOA,
  title={Effects of a bisphosphonate (1-hydroxy ethylidene-1,1 bisphosphonic acid) on osteoclast number during prolonged bed rest in healthy humans.},
  author={Daniel Chappard and Christian Alexandre and Sabine Palle and Laurence Vico and Boris V. Morukov and S. S. Rodionova and P M Minaire and G V Riffat},
  journal={Metabolism: clinical and experimental},
  year={1989},
  volume={38 9},
  pages={822-5}
}
Acute osteoporosis is known to occur after immobilization in spinal cord injured patients and is related to an early increase in osteoclastic bone resorption. Whether osteoporosis develops in healthy immobilized human patients is still a matter of controversy. Furthermore, acute osteoporosis was thought to be a good model to study the effects of… CONTINUE READING