Effects of a TREM-Like Transcript 1–Derived Peptide During Hypodynamic Septic Shock in Pigs

@article{Derive2013EffectsOA,
  title={Effects of a TREM-Like Transcript 1–Derived Peptide During Hypodynamic Septic Shock in Pigs},
  author={Marc Derive and Amir Boufenzer and Youcef Bouazza and Fr{\'e}d{\'e}rique Groubatch and Corentine Alauzet and Damien Barraud and Alain Lozniewski and Pierre Leroy and Nguyen Tran and Sébastien Gibot},
  journal={Shock},
  year={2013},
  volume={39},
  pages={176–182}
}
ABSTRACT The objective of this study was to determine the effects of a TREM (triggering receptor expressed on myeloid cells 1)–like transcript 1–derived peptide (LR12) administration during septic shock in pigs. Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5). Two animals were operated and instrumented without the induction of peritonitis and served… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
EFFECTS OF THE TREM 1 PATHWAY MODULATION DURING HEMORRHAGIC SHOCK IN RATS
TLDR
The early modulation of the TREM-1 pathway by means of a synthetic peptide may be useful during severe hemorrhagic shock in rats in preventing organ dysfunction and improving survival. Expand
Effects of the TREM-1 pathway modulation during mesenteric ischemia-reperfusion in rats
TLDR
The modulation of the TREM-1 pathway by the means of a synthetic peptide may be useful during acute mesenteric ischemia, and was associated with cardiovascular collapse, lactic acidosis, and systemic and hepatic inflammatory response that were partly prevented by LP17 administration. Expand
Role of triggering receptor expressed on myeloid cells-1 in experimental severe acute pancreatitis
TLDR
TREM-1 may act as an important mediator for inflammation and organ injury in SAP and may be a potential therapeutic target for the development of SAP and associated organ dysfunction. Expand
Modulation of the Triggering Receptor Expressed on the Myeloid Cell Type 1 Pathway in Murine Septic Shock
TLDR
In septic rats, the TREM-1 peptides improved the hemodynamic status, attenuated the development of lactic acidosis, modulated the production of such proinflammatory cytokines as tumor necrosis factor alpha and interleukin-1β, and improved survival and the protective effect of these peptides on arterial pressure could partly be explained by a decreased production of nitric oxide. Expand
Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis
TLDR
Platelet-derived soluble TLT-1 is identified as a potent endogenous regulator of sepsis-associated inflammation and is anticipated to be important in regulating leukocyte activation during other noninfectious inflammatory disorders. Expand
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
TLDR
A critical function of TREM-1 is demonstrated in acute inflammatory responses to bacteria and it is implicate as a potential therapeutic target for septic shock. Expand
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.
TLDR
It is found that patients diagnosed with sepsis had substantial levels of soluble TLT-1 in their plasma that correlated with the presence of disseminated intravascular coagulation, and that Treml1-/- mice were predisposed to hemorrhage associated with localized inflammatory lesions. Expand
Protective Effect of HMGB1 A Box on Organ Injury of Acute Pancreatitis in Mice
TLDR
A box has remarkable protective effect against pancreatitis and associated organ injury; HMGB1 probably participates in the inflammatory reaction and organ injury of SAP as a late-acting mediator of inflammation. Expand
A Soluble Form of the Triggering Receptor Expressed on Myeloid Cells-1 Modulates the Inflammatory Response in Murine Sepsis
TLDR
Both in vitro and in vivo, a synthetic peptide mimicking a short highly conserved domain of sTREM-1 appeared to attenuate cytokine production by human monocytes and protect septic animals from hyper-responsiveness and death. Expand
Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis.
TLDR
It is implied that blockade of TREM-1 could be a new approach to rheumatic diseases that is safer than the presently available immunosuppressive treatments. Expand
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