Effects of a TREM-Like Transcript 1–Derived Peptide During Hypodynamic Septic Shock in Pigs

  title={Effects of a TREM-Like Transcript 1–Derived Peptide During Hypodynamic Septic Shock in Pigs},
  author={Marc Derive and Amir Boufenzer and Youcef Bouazza and Fr{\'e}d{\'e}rique Groubatch and Corentine Alauzet and Damien Barraud and Alain Lozniewski and Pierre Leroy and Nguyen Tran and Sebastien Gibot},
ABSTRACT The objective of this study was to determine the effects of a TREM (triggering receptor expressed on myeloid cells 1)–like transcript 1–derived peptide (LR12) administration during septic shock in pigs. Two hours after induction of a fecal peritonitis, anesthetized and mechanically ventilated adult male minipigs were randomized to receive LR12 (n = 6) or its vehicle alone (normal saline, n = 5). Two animals were operated and instrumented without the induction of peritonitis and served… 

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