Effects of a Na+/Ca2+ exchanger inhibitor on pulmonary vein electrical activity and ouabain-induced arrhythmogenicity.

@article{Wongcharoen2006EffectsOA,
  title={Effects of a Na+/Ca2+ exchanger inhibitor on pulmonary vein electrical activity and ouabain-induced arrhythmogenicity.},
  author={Wanwarang Wongcharoen and Yao-Chang Chen and Yi-Jen Chen and Che-Ming Chang and H. -S. Yeh and C Lin and Shih-Ann Chen},
  journal={Cardiovascular research},
  year={2006},
  volume={70 3},
  pages={497-508}
}
OBJECTIVE Pulmonary veins (PVs) are the most important focus for generation of atrial fibrillation. The Na(+)/Ca(2+) exchange (NCX) current is important in PV electrical activity and cardiac glycosides-induced arrhythmias. The purpose of this study was to investigate whether KB-R7943, a NCX current blocker with preferential inhibition of the Ca(2+) influx, may alter PV electrophysiological characteristics and reduce glycoside-induced arrhythmogenicity. METHODS Conventional microelectrodes… CONTINUE READING
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