Effects of a α2C-Adrenoreceptor Gene Polymorphism on Neural Responses to Facial Expressions in Depression

  title={Effects of a α2C-Adrenoreceptor Gene Polymorphism on Neural Responses to Facial Expressions in Depression},
  author={Alexander Neumeister and Wayne C. Drevets and Inna Belfer and David A. Luckenbaugh and Shannan Henry and Omer Bonne and Peter Herscovitch and David Goldman and Dennis S. Charney},
Alterations in processing of emotionally salient information have been reported in individuals with major depressive disorder (MDD). Evidence suggests a role for noradrenaline in the regulation of a cortico-limbic-striatal circuit that has also been implicated in the pathophysiology of MDD. Herein, we studied the physiological consequences of a common coding polymorphism of the gene for the α2C-adrenoreceptor (AR) subtype—the deletion of four consecutive amino acids at codons 322–325 of the α2C… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 42 references

Abnormal hemodynamic responses to facially expressed emotion in major depression

WC Drevets, C Gautier, +3 authors D Kupfer
Soc Neurosci Abstr 31. • 2001
View 5 Excerpts
Highly Influenced

Structured Clinical Interview for DSM-IV Axis I Disorders: Nonpatient Edition (SCID-I/NP)

MB First, M Gibbon, RL Spitzer, JBW Williams
Biometrics Department, New York State Psychiatric Institute: New York. • 1996
View 1 Excerpt
Highly Influenced

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