Effects of a α2C-Adrenoreceptor Gene Polymorphism on Neural Responses to Facial Expressions in Depression

@article{Neumeister2006EffectsOA,
  title={Effects of a α2C-Adrenoreceptor Gene Polymorphism on Neural Responses to Facial Expressions in Depression},
  author={Alexander Neumeister and Wayne C. Drevets and Inna Belfer and David A. Luckenbaugh and Shannan Henry and Omer Bonne and Peter Herscovitch and David Goldman and Dennis S. Charney},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={1750-1756}
}
Alterations in processing of emotionally salient information have been reported in individuals with major depressive disorder (MDD). Evidence suggests a role for noradrenaline in the regulation of a cortico-limbic-striatal circuit that has also been implicated in the pathophysiology of MDD. Herein, we studied the physiological consequences of a common coding polymorphism of the gene for the α2C-adrenoreceptor (AR) subtype—the deletion of four consecutive amino acids at codons 322–325 of the α2C… CONTINUE READING

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