Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans

@article{Cameron2000EffectsOY,
  title={Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans},
  author={Oliver G. Cameron and Jon-Kar Zubieta and Leon J. Grunhaus and Satoshi Minoshima},
  journal={Psychosomatic Medicine},
  year={2000},
  volume={62},
  pages={549-559}
}
Objective Increases in adrenergic activity are associated with stress, anxiety, and other psychiatric, neurological, and medical disorders. To improve understanding of normal CNS adrenergic function, CBF responses to adrenergic stimulation were determined. Methods Using PET, the CBF changes after intravenous yohimbine, an &agr;2-adrenoreceptor antagonist that produces adrenergic activation, were compared with placebo in nine healthy humans. Heart rate, blood pressure, Paco2, plasma… 
View on Wolters Kluwer
ncbi.nlm.nih.gov
60 Citations
Highly Influential Citations
4
Background Citations
25
Results Citations
5

60 Citations

Regional Brain Activation Due to Pharmacologically Induced Adrenergic Interoceptive Stimulation in Humans
TLDR
These results demonstrate the involvement of specific brain regions as well as hemispheric laterality of function in visceral perception, and suggest that during emotional reactions involving changes in visceral organ function, activation of some of the brain regions observed could be due specifically to interoceptive processes.
Acute Yohimbine Increases Laboratory-Measured Impulsivity in Normal Subjects
nxious and Depressive Disorders and Their omorbidity : Effect on Central Nervous System oradrenergic Function liver
TLDR
With use of pure depression and anxiety groups and careful control of other factors known to affect GH, these results emonstrate central nervous system noradrenergic dysfunction in anxiety disorders.
Differential Effect of Orexin-1 and CRF-1 Antagonism on Stress Circuits: a fMRI Study in the Rat with the Pharmacological Stressor Yohimbine
TLDR
The differential pattern of inhibition produced by CRF1R and OX1R antagonists suggests that these two neuropeptide systems can modulate the functional response to stress via distinct central neural pathways.
SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence
TLDR
On a background of widespread low-amplitude perfusion decrease, caffeine activates a few regions mainly involved in the control of vigilance, anxiety, and cardiovascular regulation, but does not affect areas involved in reinforcing and reward.
Noradrenergic Modulation of the Basolateral Amygdala: Alterations by Stress Exposure
TLDR
The data demonstrate that prolonged stress alters the way in which NE affects neuronal activity in target regions, and suggest BLA neurons become hyperexcitable, and this pathology may underlie some of the behavioral deficits and symptoms associated with exposure to chronic stress.
Title Gender-specific abnormalities in the serotonin transportersystem in panic disorder
TLDR
The finding that 5-HTT-binding is elevated in males but not in females with PD converges with other evidence suggesting that dysfunction within the central serotonergic system exists in PD, and indicates that such abnormalities are influenced by gender.
Gender-specific abnormalities in the serotonin transporter system in panic disorder.
TLDR
The finding that 5-HTT-binding is elevated in males but not in females with PD converges with other evidence suggesting that dysfunction within the central serotonergic system exists in PD, and indicates that such abnormalities are influenced by gender.
The role of hyperventilation: hypocapnia in the pathomechanism of panic disorder.
TLDR
A profile of panic disorder based on and generalized from the effects of acute and chronic hyperventilation that are characteristic of the respiratory panic disorder subtype is presented.
Yohimbine increases opioid-seeking behavior in heroin-dependent, buprenorphine-maintained individuals
TLDR
These findings concur with preclinical data by demonstrating that yohimbine increases drug seeking; in this study, these effects occurred without clinically significant subjective distress or elevated craving, and partly depended on opioid unit dose.
...
...

References

SHOWING 1-10 OF 136 REFERENCES
Noradrenergic function in panic anxiety. Effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder.
TLDR
There were significant correlations between the yohimbine-induced rise in plasma MHPG level and patient-rated anxiety and nervousness and the frequency of reported panic attacks and it is suggested that impaired presynaptic noradrenergic neuronal regulation may exist in patients with frequent panic attacks.
Noradrenergic response to intravenous yohimbine in patients with depression and comorbidity of depression and panic
Platelet alpha2-Adrenoreceptors, Catecholamines, Hemodynamic Variables, and Anxiety in Panic Patients and Their Asymptomatic Relatives
TLDR
Both patients and relatives of patients showed significantly increased standing plasma norepinephrine in comparison to controls, suggesting there is a state-related decrease in binding, associated with symptom severity and norpinephrine, in panic disorder.
Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder.
TLDR
There was a significant difference in brain metabolic response to yohimbine in patients with PTSD compared with healthy subjects in prefrontal, temporal, parietal, and orbitofrontal cortexes.
Noradrenergic neuronal dysregulation in panic disorder: the effects of intravenous yohimbine and clonidine in panic disorder patients
TLDR
The behavioral, biochemical and cardiovascular effects of intravenous yohimbine and clonidine were determined and are consistent with a large body of preclinical and human data relating increased noradrenergic neuronal function to human anxiety and fear states.
Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbine-induced panic attacks.
TLDR
The hypothesis relating high noradrenergic neuronal activity to the pathophysiology of panic attacks in a subgroup of panic disorder patients is supported.
Quantitative changes in regional cerebral blood flow of rats induced by alpha- and beta-adrenergic stimulants.
TLDR
The experiments show the presence and heterogenous distribution in the cerebrovascular bed of slpha- and beta-adrenoceptors that can be activated by sympathomimetics given systematically and if noradrenaline was allowed to pass the blood-brain barrier after osmotic opening with urea, an increased regional flow was obtained.
The effect of intracarotid epinephrine, norepinephrine, and angiotensin on the regional cerebral blood flow in man
TLDR
In the present study cerebral blood flow was measured simultaneously in multiple small areas of the brain of nonanesthetized man during direct intracarotid infusion of the drugs.
Cardiac chronotropic organization of the rat insular cortex
Neuroanatomical correlates of a lactate-induced anxiety attack.
TLDR
Positron emission tomographic measurements of regional blood flow were used to assess local neuronal activity in patients with panic disorder and in normal control subjects before and during the infusion of sodium lactate and the identified regions seemed to be involved in an anxiety attack.
...
...