Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans

@article{Cameron2000EffectsOY,
  title={Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans},
  author={Oliver G. Cameron and Jon-Kar Zubieta and Leon J. Grunhaus and Satoshi Minoshima},
  journal={Psychosomatic Medicine},
  year={2000},
  volume={62},
  pages={549-559}
}
Objective Increases in adrenergic activity are associated with stress, anxiety, and other psychiatric, neurological, and medical disorders. To improve understanding of normal CNS adrenergic function, CBF responses to adrenergic stimulation were determined. Methods Using PET, the CBF changes after intravenous yohimbine, an &agr;2-adrenoreceptor antagonist that produces adrenergic activation, were compared with placebo in nine healthy humans. Heart rate, blood pressure, Paco2, plasma… 
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