Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans

  title={Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans},
  author={O. Cameron and J. Zubieta and L. Grunhaus and S. Minoshima},
  journal={Psychosomatic Medicine},
  • O. Cameron, J. Zubieta, +1 author S. Minoshima
  • Published 2000
  • Medicine
  • Psychosomatic Medicine
  • Objective Increases in adrenergic activity are associated with stress, anxiety, and other psychiatric, neurological, and medical disorders. To improve understanding of normal CNS adrenergic function, CBF responses to adrenergic stimulation were determined. Methods Using PET, the CBF changes after intravenous yohimbine, an &agr;2-adrenoreceptor antagonist that produces adrenergic activation, were compared with placebo in nine healthy humans. Heart rate, blood pressure, Paco2, plasma… CONTINUE READING
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