Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence

  title={Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence},
  author={R. Nasimi Doost Azgomi and A. Zomorrodi and H. Nazemyieh and S. M. B. Fazljou and H. Sadeghi Bazargani and F. Nejatbakhsh and A. Moini Jazani and Y. Ahmadi AsrBadr},
  journal={BioMed Research International},
Introduction Withania somnifera (WS) also known as ashwagandha is a well-known medicinal plant used in traditional medicine in many countries for infertility treatment. The present study was aimed at systemically reviewing therapeutic effects of WS on the reproductive system. Methods This systematic review study was designed in 2016. Required data were obtained from PubMed, Scopus, Google Scholar, Cochrane Library, Science Direct, Web of Knowledge, Web of Science, and manual search of articles… Expand
Effect of Withania somnifera in the treatment of male infertility: A literature review
To review data available in the literature on the effect of W. somnifera in the treatment of male infertility, the Pubmed, Lilacs and Medline databases from 2009 to 2019 were searched and 9 articles selected, including intervention articles, systematic review and meta-analysis were selected. Expand
Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective
This review focuses on folk medicinal uses, phytochemistry, pharmacological, and nutrapharmaceutical potential of the versatile plant, which may be attributed to the withanolide alkaloids. Expand
Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple‐blind randomised clinical trial
W. somnifera, a traditional medicine remedy, improves sperms parameters in idiopathic male infertility without causing adverse effects and can be considered to be an alternative to pentoxifylline in this regard. Expand
Ashwagandha (Withania somnifera) for the treatment and enhancement of mental and physical conditions: A systematic review of human trials
The results from this systematic review suggest ashwagandha has a potentially large array of therapeutic applications, however, the significant heterogeneity across studies and the limited number of investigations means further research utilising robust and adequately-powered study designs are required. Expand
Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis
The meta-analytic approaches of the included studies revealed that Ashwagandha supplementation was more efficacious than placebo for improving variables related to physical performance in healthy men and female, and Bayesian models showed that future interventions might be at least in some way beneficial on the analyzed outcomes considering the 95% credible intervals for the meta-Analytic effect size. Expand
Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management
A research synthesis of in silico, in vitro, in vivo, and clinical studies on Withania somnifera (L.) Dunal (WS) is presented and its potential for prophylaxis and management of COVID-19 is discussed. Expand
Effects of withania somnifera root extracts on serotonin secretion in suiz albino mice
Pain is a common manifestation of presence of disease or physical injury in humans. High levels of serotonin in the plasma has been associated with pain. This study aimed at determining the effect ofExpand
A Review on Phytomedicine and Their Mechanism of Action on PCOS
Polycystic ovary syndrome (PCOS) is a complex endocrinal reproductive disorder in a coalition with metabolic abnormalities of women at reproductive stages. PCOS characterized by hypergonadotropism,Expand
A Comprehensive Review and Perspective on Anticancer Mechanisms of Withaferin A in Breast Cancer
  • Eun-Ryeong Hahm, Su-Hyeong Kim, Krishna B. Singh, Kamayani Singh, Shivendra V. Singh
  • Medicine
  • Cancer Prevention Research
  • 2020
Findings on anticancer pharmacology of WA in breast cancer focusing on pharmacokinetic behavior, in vivo efficacy data in preclinical models in a therapeutic and chemoprevention settings, and its known effects on cancer-relevant cellular processes and molecular targets are summarized. Expand
Herbal medicine used to treat andrological problems: Middle East
Abstract The Middle East area, with its various climates, is rich in a significant number of plant species with medicinal properties. Traditional medical doctrines of Middle East countries such asExpand


Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity, indicating this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Expand
Spermicidal activity and antifertility activity of ethanolic extract of Withania somnifera in male albino rats
The aim of this study is to highlight the work on plant drugs and their bioactive extracts involved in male anti-fertility mechanism. The ethanol extract of Withania somnifera was found to be waterExpand
Pharmacological Evaluation of Ayurvedic Plants for Aphrodisiac Activity in Experimental Animals
From the present study, it could be concluded that A. indicum and W. somnifera both possessed marked aphrodisiac activity complying many facets such as enhancement in libido, increase in the sexual performance, penile erection and anabolism, increased spermatogenesis as well as sperm validity. Expand
Withania somnifera aqueous extract facilitates the expression and release of GnRH: In vitro and in vivo study
Significant morphological and physiological changes in GnV-3 cells after treatment with Ashwagandha extract are demonstrated and may suggest the potential beneficial effects of Ashwakandha on reproductive functions in vivo. Expand
Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study
Evidence is added on the therapeutic value of Ashwagandha (Withania somnifera), as attributed in Ayurveda for the treatment of oligospermia leading to infertility, on day 90 from baseline with a significantly greater improvement and regulation in serum hormone levels. Expand
The review reveals that many phytochemically active constituents have been separated from the plant which act as sedative, hypnotic, GABA mimetic, hypertensive, bradycardiac, anti-stress, antitumor, antiarthritic and antibacterial agents. Expand
Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats
There was significant reversal in the parameters denoting that Withania somnifera possesses antioxidant and rejuvenating property but also maintains the cellular integrity of testicular cells leading to normal functioning of it. Expand
Withania somnifera Improves Semen Quality in Stress-Related Male Fertility
A definite role of stress in male infertility and the ability of W. somnifera to treat stress-related infertility is suggested and treatment resulted in a decrease in stress, improved the level of anti-oxidants and improved overall semen quality in a significant number of individuals. Expand
Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study
This study demonstrated that oral administration of HCARE may improve sexual function in healthy women. Expand
Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males.
The treatment with W. somnifera effectively reduced oxidative stress, as assessed by decreased levels of various oxidants and improved level of diverse antioxidants, and good indicators of semen quality, were also reversed in infertile subjects after treatment with the herbal preparation. Expand